ewoc (version 0.3.0)

pdlt_d1ph: Generating a probability of DLT function based on the EWOC Proportional Hazards model

Description

Generating a probability of DLT function based on the EWOC Proportional Hazards model

Usage

pdlt_d1ph(rho, mtd, shape = NULL, theta, min_dose, max_dose, tau, distribution)

Arguments

rho

a numerical value indicating the true value of the parameter rho.

mtd

a numerical value indicating the true value of the parameter mtd.

shape

a numerical value indicating the true value of the parameter shape. It is only necessary if 'distribution' = "weibull".

theta

a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD.

min_dose

a numerical value defining the lower bound of the support of the MTD.

max_dose

a numerical value defining the upper bound of the support of the MTD.

tau

a numerical value defining the period of time for a possible toxicity be observed.

distribution

a character establishing the distribution for the time of events. It can be defined as 'exponential' or 'weibull'.

Value

A function with dose as an input and a probability based on the logistic regression and parameters as an output.

Examples

# NOT RUN {
pdlt <- pdlt_d1ph(rho = 0.05, mtd = 40, theta = 0.33,
                 min_dose = 30, max_dose = 50,
                 tau = 10, distribution = "exponential")
pdlt(40)

# }