The mithochondiral calcium overload (MCO) was measured in two groups (control and treatment) every 10 seconds during an hour in isolated mouse cardiac cells. In fact, due to technical reasons, the original experiment [see Ruiz-Meana et al. (2000)] was performed twice, using both the "intact", original cells and "permeabilized" cells (a condition related to the mitochondrial membrane).
Elements of MCO:
..$intact: fdata class object with
``intact cells''curves,
"data": Matrix of class
fdata with 89 intact cells curves (rows) measured every 10 seconds
during an hour in isolated mouse cardiac cell.
"argvals", 360
discretization points from seond 0 to 3590.
"rangeval":
range("argvals").
"names" list with: main an
overall title "Control Intact Treatment", xlab title for x
axis "seconds" and ylab title for y axis "Ca".
..$classintact: Factor levels of ``intact cells'' curves: "1" control
group and "2" treatment group.
..$permea: fdata class object with ``permeabilized cells''
curves (whose membrane has been removed),
"data":
Matrix of class fdata with 90 permeabilizzed cells curves (rows)
measured every 10 seconds during an hour in isolated mouse cardiac cell.
"argvals", 360 discretization points from seond 0 to 3590.
"rangeval": range("argvals").
"names" list
with: main an overall title "Control Intact Treatment", xlab
title for x axis "seconds" and ylab title for y axis
"Ca".
..$classpermea: Factor levels of ``permeabilized cells''
curves: "1" control group and "2" treatment group.
Ruiz--Meana M, Garcia-Dorado D, Pina P, Inserte J, Agullo L, Soler--Soler J. Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions. American Journal Physiology Heart Circulatori Physiology. 2003 Sep;285(3):H999--1006.
data(MCO)
names(MCO)
par(mfrow=c(1,2))
plot(MCO$intact,col=MCO$classintact)
plot(MCO$permea,col=MCO$classpermea)
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