create_fs_subgroup_indicators

Internal helper to create Qrecommend and Brecommend indicator columns.

internal

Implements statistical methods for exploratory subgroup identification
in clinical trials with survival endpoints. Provides tools for identifying
patient subgroups with differential treatment effects using machine learning
approaches including Generalized Random Forests (GRF), LASSO regularization,
and exhaustive combinatorial search algorithms. Features bootstrap bias
correction using infinitesimal jackknife methods to address selection bias
in post-hoc analyses. Designed for clinical researchers conducting exploratory
subgroup analyses in randomized controlled trials, particularly for
multi-regional clinical trials (MRCT) requiring regional consistency
evaluation. Supports both accelerated failure time (AFT) and Cox proportional
hazards models with comprehensive diagnostic and visualization tools.
Methods are described in León et al. (2024) <doi:10.1002/sim.10163>.

Larry Leon

forestsearch

Exploratory Subgroup Identification in Clinical Trials with
Survival Endpoints

create_fs_subgroup_indicators function

<dl><dt>df</dt>
<dd>Data frame to modify.</dd>
<dt>fs.est</dt>
<dd>A forestsearch object.</dd>
<dt>col_names</dt>
<dd>Character vector of length 2. Names for the indicator
columns: first for harm/questionable (treat.recommend == 0),
second for benefit/recommend (treat.recommend == 1).
Default: c("Qrecommend", "Brecommend")</dd>
<dt>verbose</dt>
<dd>Logical. Print diagnostic messages.</dd></dl>

Arguments

Create Subgroup Indicator Columns from ForestSearch — create_fs_subgroup_indicators

<dl>

<dt>df</dt>
<dd>Data frame to modify.</dd>


<dt>fs.est</dt>
<dd>A forestsearch object.</dd>


<dt>col_names</dt>
<dd>Character vector of length 2. Names for the indicator
columns: first for harm/questionable (treat.recommend == 0),
second for benefit/recommend (treat.recommend == 1).
Default: c("Qrecommend", "Brecommend")</dd>


<dt>verbose</dt>
<dd>Logical. Print diagnostic messages.</dd>

</dl>

create_fs_subgroup_indicators: Create Subgroup Indicator Columns from ForestSearch

Description

Usage

Value

Arguments