extract_grf_estimates

Aligned with new DGM output structure including AHR metrics.
Correctly handles grf.subg.harm.survival() output structure:<ul>
<li>sg.harm.id: subgroup definition string</li>
<li>data: data frame with treat.recommend column (0 = harm, 1 = complement)</li>
</ul>

internal

Implements statistical methods for exploratory subgroup identification
in clinical trials with survival endpoints. Provides tools for identifying
patient subgroups with differential treatment effects using machine learning
approaches including Generalized Random Forests (GRF), LASSO regularization,
and exhaustive combinatorial search algorithms. Features bootstrap bias
correction using infinitesimal jackknife methods to address selection bias
in post-hoc analyses. Designed for clinical researchers conducting exploratory
subgroup analyses in randomized controlled trials, particularly for
multi-regional clinical trials (MRCT) requiring regional consistency
evaluation. Supports both accelerated failure time (AFT) and Cox proportional
hazards models with comprehensive diagnostic and visualization tools.
Methods are described in León et al. (2024) <doi:10.1002/sim.10163>.

Larry Leon

forestsearch

Exploratory Subgroup Identification in Clinical Trials with
Survival Endpoints

extract_grf_estimates function

<dl><dt>df</dt>
<dd>Simulated data frame</dd>
<dt>grf_est</dt>
<dd>GRF estimation result from grf.subg.harm.survival()</dd>
<dt>dgm</dt>
<dd>DGM object</dd>
<dt>cox_formula</dt>
<dd>Cox formula</dd>
<dt>cox_formula_adj</dt>
<dd>Adjusted Cox formula</dd>
<dt>analysis</dt>
<dd>Analysis label</dd>
<dt>frac_tau</dt>
<dd>Fraction of tau used</dd>
<dt>verbose</dt>
<dd>Print extraction details</dd>
<dt>debug</dt>
<dd>Print detailed debugging information about GRF result structure</dd></dl>

Arguments

Extract Estimates from GRF Results — extract_grf_estimates

<dl>

<dt>df</dt>
<dd>Simulated data frame</dd>


<dt>grf_est</dt>
<dd>GRF estimation result from grf.subg.harm.survival()</dd>


<dt>dgm</dt>
<dd>DGM object</dd>


<dt>cox_formula</dt>
<dd>Cox formula</dd>


<dt>cox_formula_adj</dt>
<dd>Adjusted Cox formula</dd>


<dt>analysis</dt>
<dd>Analysis label</dd>


<dt>frac_tau</dt>
<dd>Fraction of tau used</dd>


<dt>verbose</dt>
<dd>Print extraction details</dd>


<dt>debug</dt>
<dd>Print detailed debugging information about GRF result structure</dd>

</dl>

extract_grf_estimates: Extract Estimates from GRF Results

Description

Usage

Value

Arguments