format_bootstrap_table

Creates a publication-ready table from ForestSearch bootstrap results,
with bias-corrected confidence intervals, informative formatting, and
optional subgroup definition footnote.

internal

Implements statistical methods for exploratory subgroup identification
in clinical trials with survival endpoints. Provides tools for identifying
patient subgroups with differential treatment effects using machine learning
approaches including Generalized Random Forests (GRF), LASSO regularization,
and exhaustive combinatorial search algorithms. Features bootstrap bias
correction using infinitesimal jackknife methods to address selection bias
in post-hoc analyses. Designed for clinical researchers conducting exploratory
subgroup analyses in randomized controlled trials, particularly for
multi-regional clinical trials (MRCT) requiring regional consistency
evaluation. Supports both accelerated failure time (AFT) and Cox proportional
hazards models with comprehensive diagnostic and visualization tools.
Methods are described in León et al. (2024) <doi:10.1002/sim.10163>.

Larry Leon

forestsearch

Exploratory Subgroup Identification in Clinical Trials with
Survival Endpoints

format_bootstrap_table function

<dl><dt>FSsg_tab</dt>
<dd>Data frame or matrix from forestsearch_bootstrap_dofuture()$FSsg_tab</dd>
<dt>nb_boots</dt>
<dd>Integer. Number of bootstrap iterations performed</dd>
<dt>est.scale</dt>
<dd>Character. "hr" or "1/hr" for effect scale</dd>
<dt>boot_success_rate</dt>
<dd>Numeric. Proportion of bootstraps that found subgroups</dd>
<dt>sg_definition</dt>
<dd>Character. Subgroup definition string to display as footnote
(e.g., "{age&gt;=50} &amp; {nodes&gt;=3}"). If NULL, no subgroup footnote is added.</dd>
<dt>title</dt>
<dd>Character. Custom title (optional)</dd>
<dt>subtitle</dt>
<dd>Character. Custom subtitle (optional)</dd></dl>

Arguments

Format Bootstrap Results Table with gt — format_bootstrap_table

<dl>

<dt>FSsg_tab</dt>
<dd>Data frame or matrix from forestsearch_bootstrap_dofuture()$FSsg_tab</dd>


<dt>nb_boots</dt>
<dd>Integer. Number of bootstrap iterations performed</dd>


<dt>est.scale</dt>
<dd>Character. "hr" or "1/hr" for effect scale</dd>


<dt>boot_success_rate</dt>
<dd>Numeric. Proportion of bootstraps that found subgroups</dd>


<dt>sg_definition</dt>
<dd>Character. Subgroup definition string to display as footnote
(e.g., "{age&gt;=50} &amp; {nodes&gt;=3}"). If NULL, no subgroup footnote is added.</dd>


<dt>title</dt>
<dd>Character. Custom title (optional)</dd>


<dt>subtitle</dt>
<dd>Character. Custom subtitle (optional)</dd>

</dl>

format_bootstrap_table: Format Bootstrap Results Table with gt

Description

Usage

Value

Arguments