get_targetEst

Calculates target estimate and standard error for bootstrap samples.

internal

Implements statistical methods for exploratory subgroup identification
in clinical trials with survival endpoints. Provides tools for identifying
patient subgroups with differential treatment effects using machine learning
approaches including Generalized Random Forests (GRF), LASSO regularization,
and exhaustive combinatorial search algorithms. Features bootstrap bias
correction using infinitesimal jackknife methods to address selection bias
in post-hoc analyses. Designed for clinical researchers conducting exploratory
subgroup analyses in randomized controlled trials, particularly for
multi-regional clinical trials (MRCT) requiring regional consistency
evaluation. Supports both accelerated failure time (AFT) and Cox proportional
hazards models with comprehensive diagnostic and visualization tools.
Methods are described in León et al. (2024) <doi:10.1002/sim.10163>.

Larry Leon

forestsearch

Exploratory Subgroup Identification in Clinical Trials with
Survival Endpoints

get_targetEst function

<dl><dt>x</dt>
<dd>Numeric vector of estimates.</dd>
<dt>ystar</dt>
<dd>Matrix of bootstrap samples.</dd>
<dt>cov_method</dt>
<dd>Character. Covariance method ("standard" or "nocorrect").</dd>
<dt>cov_trim</dt>
<dd>Numeric. Trimming proportion for covariance (default: 0.0).</dd></dl>

Arguments

Target Estimate and Standard Error for Bootstrap — get_targetEst

<dl>

<dt>x</dt>
<dd>Numeric vector of estimates.</dd>


<dt>ystar</dt>
<dd>Matrix of bootstrap samples.</dd>


<dt>cov_method</dt>
<dd>Character. Covariance method ("standard" or "nocorrect").</dd>


<dt>cov_trim</dt>
<dd>Numeric. Trimming proportion for covariance (default: 0.0).</dd>

</dl>

get_targetEst: Target Estimate and Standard Error for Bootstrap

Description

Usage

Value

Arguments