run_grf_analysis

Helper function to run standalone GRF analysis using grf.subg.harm.survival().

internal

Implements statistical methods for exploratory subgroup identification
in clinical trials with survival endpoints. Provides tools for identifying
patient subgroups with differential treatment effects using machine learning
approaches including Generalized Random Forests (GRF), LASSO regularization,
and exhaustive combinatorial search algorithms. Features bootstrap bias
correction using infinitesimal jackknife methods to address selection bias
in post-hoc analyses. Designed for clinical researchers conducting exploratory
subgroup analyses in randomized controlled trials, particularly for
multi-regional clinical trials (MRCT) requiring regional consistency
evaluation. Supports both accelerated failure time (AFT) and Cox proportional
hazards models with comprehensive diagnostic and visualization tools.
Methods are described in León et al. (2024) <doi:10.1002/sim.10163>.

Larry Leon

forestsearch

Exploratory Subgroup Identification in Clinical Trials with
Survival Endpoints

run_grf_analysis function

<dl><dt>data</dt>
<dd>Data frame with simulated trial data</dd>
<dt>confounders_name</dt>
<dd>Character vector of confounder names</dd>
<dt>params</dt>
<dd>List of GRF parameters (from grf_merged)</dd>
<dt>dgm</dt>
<dd>DGM object for computing true HRs</dd>
<dt>cox_formula</dt>
<dd>Cox formula for estimation</dd>
<dt>cox_formula_adj</dt>
<dd>Adjusted Cox formula</dd>
<dt>analysis_label</dt>
<dd>Character label for this analysis</dd>
<dt>verbose</dt>
<dd>Print details</dd>
<dt>debug</dt>
<dd>Print detailed debugging information</dd></dl>

Arguments

Run GRF Analysis — run_grf_analysis

<dl>

<dt>data</dt>
<dd>Data frame with simulated trial data</dd>


<dt>confounders_name</dt>
<dd>Character vector of confounder names</dd>


<dt>params</dt>
<dd>List of GRF parameters (from grf_merged)</dd>


<dt>dgm</dt>
<dd>DGM object for computing true HRs</dd>


<dt>cox_formula</dt>
<dd>Cox formula for estimation</dd>


<dt>cox_formula_adj</dt>
<dd>Adjusted Cox formula</dd>


<dt>analysis_label</dt>
<dd>Character label for this analysis</dd>


<dt>verbose</dt>
<dd>Print details</dd>


<dt>debug</dt>
<dd>Print detailed debugging information</dd>

</dl>

run_grf_analysis: Run GRF Analysis

Description

Usage

Value

Arguments