summarize_simulation_results

Creates a summary table of operating characteristics across all simulations.
Includes both HR and AHR metrics.

Implements statistical methods for exploratory subgroup identification
in clinical trials with survival endpoints. Provides tools for identifying
patient subgroups with differential treatment effects using machine learning
approaches including Generalized Random Forests (GRF), LASSO regularization,
and exhaustive combinatorial search algorithms. Features bootstrap bias
correction using infinitesimal jackknife methods to address selection bias
in post-hoc analyses. Designed for clinical researchers conducting exploratory
subgroup analyses in randomized controlled trials, particularly for
multi-regional clinical trials (MRCT) requiring regional consistency
evaluation. Supports both accelerated failure time (AFT) and Cox proportional
hazards models with comprehensive diagnostic and visualization tools.
Methods are described in León et al. (2024) <doi:10.1002/sim.10163>.

Larry Leon

forestsearch

Exploratory Subgroup Identification in Clinical Trials with
Survival Endpoints

summarize_simulation_results function

<dl><dt>results</dt>
<dd>data.table with simulation results from run_simulation_analysis</dd>
<dt>analyses</dt>
<dd>Character vector. Analysis methods to include. Default: all</dd>
<dt>digits</dt>
<dd>Integer. Decimal places for proportions. Default: 2</dd>
<dt>digits_hr</dt>
<dd>Integer. Decimal places for hazard ratios. Default: 3</dd></dl>

Arguments

Summarize Simulation Results — summarize_simulation_results

<dl>

<dt>results</dt>
<dd>data.table with simulation results from run_simulation_analysis</dd>


<dt>analyses</dt>
<dd>Character vector. Analysis methods to include. Default: all</dd>


<dt>digits</dt>
<dd>Integer. Decimal places for proportions. Default: 2</dd>


<dt>digits_hr</dt>
<dd>Integer. Decimal places for hazard ratios. Default: 3</dd>

</dl>

summarize_simulation_results: Summarize Simulation Results

Description

Usage

Value

Arguments