forrel (version 1.7.1)

randomPersonEP: Random person exclusion power

Description

This is a special case of exclusionPower(), computing the power to exclude a random person as a given pedigree member. More specifically, the function computes the probability of observing, in an individual unrelated to the family individual, a genotype incompatible with the typed family members.

Usage

randomPersonEP(x, id, markers = NULL, disableMutations = NA, verbose = TRUE)

Value

The EPresult object returned by exclusionPower().

Arguments

x

A ped object with attached markers.

id

The ID label of a single pedigree member.

markers

A vector indicating the names or indices of markers attached to the source pedigree. If NULL (default), then all markers attached to the source pedigree are used. If alleles or afreq is non-NULL, then this parameter is ignored.

disableMutations

This parameter determines how mutation models are treated. Possible values are as follows:

• NA (the default): Mutations are disabled only for those markers whose known genotypes are consistent with the pedigree. This is determined by temporarily removing all mutation models and checking which markers have nonzero likelihood.

• TRUE: Mutations are disabled for all markers. This will result in an error if any markers are inconsistent.

• FALSE: No action is done to disable mutations.

• A vector containing the names or indices of those markers for which mutations should be disabled.

verbose

A logical.

Examples

# Four siblings:
x = nuclearPed(4)

# First 3 sibs typed with 4 triallelic markers
x = markerSim(x, N = 4, ids = 3:5, alleles = 1:3, seed = 577, verbose = FALSE)

# Probability that a random man is excluded as the fourth sibling
randomPersonEP(x, id = 6)