dat.copd

An illustrative example of network meta-analysis with a binary outcome.

datasets

A collection of user-friendly functions for assessing and visualizing fragility of individual studies (Walsh et al., 2014 <doi:10.1016/j.jclinepi.2013.10.019>; Lin, 2021 <doi:10.1111/jep.13428>), conventional pairwise meta-analyses (Atal et al., 2019 <doi:10.1016/j.jclinepi.2019.03.012>), and network meta-analyses of multiple treatments with binary outcomes (Xing et al., 2020 <doi:10.1016/j.jclinepi.2020.07.003>). The included functions are designed to: 1) calculate the fragility index (i.e., the minimal event status modifications that can alter the significance or non-significance of the original result) and fragility quotient (i.e., fragility index divided by sample size) at a specific significance level; 2) give the cases of event status modifications for altering the result's significance or non-significance and visualize these cases; 3) visualize the trend of statistical significance as event status is modified; 4) efficiently derive fragility indexes and fragility quotients at multiple significance levels, and visualize the relationship between these fragility measures against the significance levels; and 5) calculate fragility indexes and fragility quotients of multiple datasets (e.g., a collection of clinical trials or meta-analyses) and produce plots of their overall distributions. The outputs from these functions may inform the robustness of clinical results in terms of statistical significance and aid the interpretation of fragility measures. The usage of this package is illustrated in Lin et al. (2023 <doi:10.1016/j.ajog.2022.08.053>) and detailed in Lin and Chu (2022 <doi:10.1371/journal.pone.0268754>).

Lifeng Lin

fragility

Assessing and Visualizing Fragility of Clinical Results with
Binary Outcomes

Haitao Chu

dat.copd function

A data frame with 3 studies and 4 treatments, with the following 4 variables.<dl>
 <dt><code>sid</code></dt>
<dd>a numeric vector indicating study IDs.</dd> <dt><code>tid</code></dt>
<dd>a numeric vector indicating treatment IDs.</dd> <dt><code>e</code></dt>
<dd>a numeric vector indicating event counts.</dd> <dt><code>n</code></dt>
<dd>a numeric vector indicating sample sizes.</dd> 
</dl>

Format

Network Meta-Analysis of Chronic Obstructive Pulmonary Disease — dat.copd

A data frame with 3 studies and 4 treatments, with the following 4 variables.<dl>
 <dt><code>sid</code></dt>
<dd>a numeric vector indicating study IDs.</dd>

 <dt><code>tid</code></dt>
<dd>a numeric vector indicating treatment IDs.</dd>

 <dt><code>e</code></dt>
<dd>a numeric vector indicating event counts.</dd>

 <dt><code>n</code></dt>
<dd>a numeric vector indicating sample sizes.</dd>

 
</dl>

dat.copd: Network Meta-Analysis of Chronic Obstructive Pulmonary Disease

Description

Usage

Arguments

Format

Details