frailtypack (version 2.4.1)
General Frailty models: shared, joint and nested frailty models
with prediction
Description
Frailtypack now fits several classes of frailty models
using a penalized likelihood estimation on the hazard function
but also a parametric estimation. 1) A shared frailty model
(with gamma or log-normal frailty distribution) and Cox
proportional hazard model. Clustered and recurrent survival
times can be studied. 2) Additive frailty models for
proportional hazard models with two correlated random effects
(intercept random effect with random slope). 3) Nested frailty
models for hierarchically clustered data (with 2 levels of
clustering) by including two iid gamma random effects. 4) Joint
frailty models in the context of joint modelling for recurrent
events with terminal event for clustered data or not.
Prediction values are available. Left truncated (not for Joint
model), right-censored data, interval-censored data (only for
Cox proportional hazard and shared frailty model) and strata
(max=2) are allowed. In each model, the random effects have a
gamma distribution, but you can switch to a log-normal in
shared and joint models. Now, you can also consider
time-varying covariates effects in Cox, shared and joint
models. The package includes concordance measures for Cox
proportional hazards models and for shared frailty models.