bcos

The often used data set for interval-censored data, described and given in full in Finkelstein and Wolfe (1985).
It involves 94 breast cancer patients who were randomized to either radiation therapy with chemotherapy
or radiation therapy alone. The outcome is time until the onset of breast retraction which is interval-censored between
the last clinic visit before the event was observed and the first visit when the event was observed. Patients without breast retraction were right-censored.

datasets

Frailtypack fits several classes of frailty models using a penalized likelihood
        estimation on the hazard function but also a parametric estimation.
        1) A shared frailty model (with gamma or log-normal frailty distribution) and Cox
        proportional hazard model. Clustered and recurrent survival times can be studied.
        2) Additive frailty models for proportional hazard models with two correlated
        random effects (intercept random effect with random slope).
        3) Nested frailty models for hierarchically clustered data (with 2 levels of
        clustering) by including two iid gamma random effects.
        4) Joint frailty models in the context of joint modelling for recurrent events
        with terminal event for clustered data or not.
        Prediction values are available. Left-truncated (not for Joint model),
        right-censored data, interval-censored data (only for Cox proportional hazard
        and shared frailty model) and strata are allowed. In each model,
        the random effects have a gamma distribution, but you can switch to a log-normal
        in shared and joint models. Now, you can also consider time-varying covariates
        effects in Cox, shared and joint models. The package includes concordance measures
        for Cox proportional hazards models and for shared frailty models.

Virginie Rondeau

frailtypack

General Frailty models: shared, joint and nested frailty models
        with prediction

bcos function

Finkelstein, D.M. and Wolfe, R.A. (1985). A semiparametric model for regression analysis of interval-censored failure time data.
<em>Biometrics</em> <b>41</b>, 731-740.

bcos: Breast Cosmesis Data

Description

Usage

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source