freqMAP (version 0.2)

genotypebyage: Simulated Genotype Data by Age for 4000 Probands and 4000 Controls

Description

A simple simulated dataset comprising 4000 probands and 4000 controls, where subject age is tabulated against their genotype.

Usage

data(genotypebyage)

Format

A data frame with 8000 observations on the following 5 variables.

age

Subject age (a numeric vector)

subject.type

Subject type: proband or control (a character vector)

allele1

Subject's first allele: "a" or "b" (a character vector)

allele2

Subject's second allele: "a" or "b" (a character vector)

genotype

Subject's genotype, coded "allele1.allele2" (a character vector)

Details

This dataset is used for the examples in the main help page for the freqMAP: freqMAP-package. See there for usage details. In MAP plots as a function of age, the genotype frequency curves in this dataset demonstrate non-homogeneous frequency patterns. For instance, at ages above 70, the "b.b" genotype becomes more frequent in probands than in younger probands. To compensate, the "a.a" genotype is less frequent in older probands than younger ones. The "a.b" genotype in probands is more homogeneous over all ages. Control genotype frequencies are also relatively homogeneous over all ages.

References

Payami, H., Kay, D.M., Zabetian, C.P., Schellenberg, G.D., Factor, S.A., and McCulloch, C.C. (2009) "Visualizing Disease Associations: Graphic Analysis of Frequency Distributions as a Function of Age Using Moving Average Plots (MAP) with Application to Alzheimer's and Parkinson's Disease", Genetic Epidemiology

Examples

data(genotypebyage)