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futility: Interim Analysis of Operational Futility in Randomized Trials with Time-to-Event Endpoints and Fixed Follow-Up

futility is an R package implementing estimation and inferential procedures for assessing operational futility in randomized treatment efficacy trials with time-to-event endpoints and fixed follow-up. The procedures condition on data observed through an interim timepoint. Inference can be restricted to a 'per-protocol' cohort. Plotting functions are provided for graphical display of results.

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Install

install.packages('futility')

Monthly Downloads

180

Version

0.4

License

GPL-2

Issues

0

Pull Requests

0

Stars

1

Forks

0

Maintainer

Michal Juraska

Last Published

April 11th, 2019

Functions in futility (0.4)

plotRCDF.byArm

Plot Characteristics of the Estimated Distribution of the Treatment Arm-Specific Number of Endpoints
completeTrial.byArm

Treatment Arm-Specific Simulation-Based Completion of a Randomized Efficacy Trial with a Time-to-Event Endpoint and Fixed Follow-up Using an Interim Data-set
completeTrial.pooledArms

Treatment Arm-Pooled Simulation-Based Completion of a Randomized Efficacy Trial with a Time-to-Event Endpoint and Fixed Follow-up Using an Interim Data-set
plotRCDF.pooledArms

Plot Characteristics of the Estimated Distribution of the Treatment Arm-Pooled Number of Endpoints