gRbase (version 1.3.9)

breastcancer: Gene expression signatures for p53 mutation status in 250 breast cancer samples

Description

Perturbations of the p53 pathway are associated with more aggressive and therapeutically refractory tumours. We preprocessed the data using Robust Multichip Analysis (RMA). Dataset has been truncated to the 1000 most informative genes (as selected by Wilcoxon test statistics) to simplify computation. The genes have been standardised to have zero mean and unit variance (i.e. z-scored).

Usage

data(breastcancer)

source

Dr. Chris Holmes, c.holmes at stats dot. ox . ac .uk

Details

The factor code defines whether there was a mutation in the p53 sequence (code=case) or not (code=control).

References

Miller et al (2005, PubMed ID:16141321)

Examples

data(breastcancer)
## maybe str(breastcancer) ; plot(breastcancer) ...