The data come from a study of the effects of five dietary regimens with different fatty acid compositions on liver lipids and hepatic gene expression in 40 mice.
data(Nutrimouse)A data frame with 40 observations on the following 143 variables.
genotypea factor with levels wt
ppar
dieta factor with levels coc
fish lin ref sun
X36b4a numeric vector
ACAT1a numeric vector
ACAT2a numeric vector
ACBPa numeric vector
ACC1a numeric vector
ACC2a numeric vector
ACOTHa numeric vector
ADISPa numeric vector
ADSS1a numeric vector
ALDH3a numeric vector
AM2Ra numeric vector
AOXa numeric vector
BACTa numeric vector
BIENa numeric vector
BSEPa numeric vector
Bcl.3a numeric vector
C16SRa numeric vector
CACPa numeric vector
CAR1a numeric vector
CBSa numeric vector
CIDEAa numeric vector
COX1a numeric vector
COX2a numeric vector
CPT2a numeric vector
CYP24a numeric vector
CYP26a numeric vector
CYP27a1a numeric vector
CYP27b1a numeric vector
CYP2b10a numeric vector
CYP2b13a numeric vector
CYP2c29a numeric vector
CYP3A11a numeric vector
CYP4A10a numeric vector
CYP4A14a numeric vector
CYP7aa numeric vector
CYP8b1a numeric vector
FASa numeric vector
FATa numeric vector
FDFTa numeric vector
FXRa numeric vector
G6PDHa numeric vector
G6Pasea numeric vector
GKa numeric vector
GSa numeric vector
GSTaa numeric vector
GSTmua numeric vector
GSTpi2a numeric vector
HMGCoAreda numeric vector
HPNCLa numeric vector
IL.2a numeric vector
L.FABPa numeric vector
LCEa numeric vector
LDLra numeric vector
LPKa numeric vector
LPLa numeric vector
LXRaa numeric vector
LXRba numeric vector
Lpina numeric vector
Lpin1a numeric vector
Lpin2a numeric vector
Lpin3a numeric vector
M.CPT1a numeric vector
MCADa numeric vector
MDR1a numeric vector
MDR2a numeric vector
MRP6a numeric vector
MSa numeric vector
MTHFRa numeric vector
NGFiBa numeric vector
NURR1a numeric vector
Ntcpa numeric vector
OCTN2a numeric vector
PALa numeric vector
PDK4a numeric vector
PECIa numeric vector
PLTPa numeric vector
PMDCIa numeric vector
PONa numeric vector
PPARaa numeric vector
PPARda numeric vector
PPARga numeric vector
PXRa numeric vector
Pex11aa numeric vector
RARaa numeric vector
RARb2a numeric vector
RXRaa numeric vector
RXRb2a numeric vector
RXRg1a numeric vector
S14a numeric vector
SHP1a numeric vector
SIAT4ca numeric vector
SPI1.1a numeric vector
SR.BIa numeric vector
THBa numeric vector
THIOLa numeric vector
TRaa numeric vector
TRba numeric vector
Tpalphaa numeric vector
Tpbetaa numeric vector
UCP2a numeric vector
UCP3a numeric vector
VDRa numeric vector
VLDLra numeric vector
Waf1a numeric vector
ap2a numeric vector
apoA.Ia numeric vector
apoBa numeric vector
apoC3a numeric vector
apoEa numeric vector
c.fosa numeric vector
cHMGCoASa numeric vector
cMOATa numeric vector
eif2ga numeric vector
hABC1a numeric vector
i.BABPa numeric vector
i.BATa numeric vector
i.FABPa numeric vector
i.NOSa numeric vector
mABC1a numeric vector
mHMGCoASa numeric vector
C14.0a numeric vector
C16.0a numeric vector
C18.0a numeric vector
C16.1n.9a numeric vector
C16.1n.7a numeric vector
C18.1n.9a numeric vector
C18.1n.7a numeric vector
C20.1n.9a numeric vector
C20.3n.9a numeric vector
C18.2n.6a numeric vector
C18.3n.6a numeric vector
C20.2n.6a numeric vector
C20.3n.6a numeric vector
C20.4n.6a numeric vector
C22.4n.6a numeric vector
C22.5n.6a numeric vector
C18.3n.3a numeric vector
C20.3n.3a numeric vector
C20.5n.3a numeric vector
C22.5n.3a numeric vector
C22.6n.3a numeric vector
The data come from a study of the effects of five dietary regimens with different fatty acid compositions on liver lipids and hepatic gene expression in wild-type and PPAR-alpha-deficient mice (Martin et al., 2007).
There were 5 replicates per genotype and diet combination.
There are two design variables: (i) genotype, a factor with two levels: wild-type (wt) and PPAR-alpha-deficient (ppar), and (ii) diet, a factor with five levels. The oils used for experimental diet preparation were: corn and colza oils (50/50) for a reference diet (ref); hydrogenated coconut oil for a saturated fatty acid diet (coc); sunflower oil for an Omega6 fatty acid-rich diet (sun); linseed oil for an Omega3-rich diet (lin); and corn/colza/enriched (43/43/14) fish oils (fish).
There are 141 response variables: (i) the log-expression levels of 120 genes measured in liver cells, and (ii) the concentrations (in percentages) of 21 hepatic fatty acids measured by gas chromatography.
Martin, P. G. P., Guillou, H., Lasserre, F., D<e9>jean, S., Lan, A., Pascussi, J.-M., San Cristobal, M., Legrand, P., Besse, P. and Pineau, T. (2007). Novel aspects of PPARa-mediated regulation of lipid and xenobiotic metabolism revealed through a multrigenomic study. Hepatology 54, 767-777.
# NOT RUN {
data(Nutrimouse)
# }
Run the code above in your browser using DataLab