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gammaFuncModel (version 5.0)

Non-Linear Mixed Effects Model Based on the Gamma Function Form

Description

Identifies biomarkers that exhibit differential response dynamics by time across groups and estimates kinetic properties of biomarkers.

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Version

Install

install.packages('gammaFuncModel')

Monthly Downloads

132

Version

5.0

License

GPL

Maintainer

Hongting Chen

Last Published

June 20th, 2025

Functions in gammaFuncModel (5.0)

calculate_half_life

Function that produces Half-life property for a single individual in a particular group, for a specific metabolite
grpResp2Time_parallel

Vectorized version of grpRes2Time()
grpResp2Time

Function that produces a summary table for coefficient estimates, their p-values and LRT p-values for every metabolite in the dataframe, for a single Group
calculate_AUC

Function that produces Area Under the Curve(AUC) property for a single individual in a particular group, for a specific metabolite
gammaFunction

Implementation of the novel non-linear mixed-effects model based on gamma function form with nested covariance structure where random effects are specified for each Diet level within each subject (ID), capturing within-subject correlation across dietary conditions. to identify metabolites that responds to time differentially across dietary groups
diffGrpResponse

Function that produces a summary table for coefficient estimates, their p-values and LRT p-values for every metabolite in the dataframe
generate_models

Function that produces a fitted gamma model for each metabolite
calculate_Tmax

Function that produces Tmax property for a single individual in a particular group, for a specific metabolite
generate_f_function

Function produce predictions from the model
calculate_Cmax

Function that produces Cmax property for a single individual in a particular group, for a specific metabolite
generatePlot

Function that generate plots for metabolite models
diffGrpResponse_parallel

Parallelized version of diffGrpResponse()
pk_calculation

Function that returns a data frame for Tmax, Cmax, half-life, AUC and AUCInf for metabolites