gen2single: Generalized exact single stage phase II design

Description

Calculates the generalized exact one stage phase II design based on the R function ph2single.

Usage

gen2single(pu,pa,ep1,ep2,nsoln=5)
# S3 method for gen2single
print(x, …)

Arguments

unacceptable response/toxicity rate

response/toxicity rate that is desirable

ep1

threshold for the probability of declaring drug/treatment desirable under p0

ep2

threshold for the probability of rejecting the drug/treatment under p1

nsoln

number of designs with given alpha and beta

object returned by gen2single

...

arguments to be passed onto print command called within

Value

gen2single returns the optimal design with pu, pa, alpha, and beta as above and:

out

matrix of the single-stage designs up to nsoln. The 4 columns are: r, n, alpha (type I error), beta (type II erro)

The "print" method formats and returns the optimal design.

References

Kim S and Wong WK. Phase II Two-Stage Single-Arm Clinical Trials for Testing Toxicity Levels. Commun Stat Appl Methods. 2019 Mar;26(2):163-173. https://www.ncbi.nlm.nih.gov/pubmed/31106162.

Examples

Run this code

# NOT RUN {
  # Single-stage safety design with pu (p0) = 0.33 vs. pa (p1) = 0.20
  gen2single(0.33, 0.20, 0.05, 0.20)

  # Single-stage efficacy design with pu (p0) = 0.67 vs. pa (p1) = 0.80
  gen2single(0.67, 0.80, 0.05, 0.20)

  # save and print
  safety1 = gen2single(0.33, 0.20, 0.05, 0.20)
  print(safety1)
# }