gen2stage (version 1.0)

oc.gentwostage.bdry: Two-stage boundary operating characteristics

Description

Calculates the operating characteristics of a two-stage boundary based on the R function oc.twostage.bdry.

Usage

oc.gentwostage.bdry(pu, pa, r1, n1, r, n)

Arguments

pu

unacceptable response rate

pa

response rate that is desirable

r1

first stage threshold to declare treatment undesirable

n1

first stage sample size

r

overall threshold to declare treatment undesirable

n

total sample size

Value

oc.gentwostage.bdry returns the type I and II error rates as well as the probability of early temination and expected sample size under pu for a specific boundary.

References

Kim S and Wong WK. Phase II Two-Stage Single-Arm Clinical Trials for Testing Toxicity Levels. Commun Stat Appl Methods. 2019 Mar;26(2):163-173. https://www.ncbi.nlm.nih.gov/pubmed/31106162.

See Also

gen2simon

Examples

# NOT RUN {
  # Optimal two-stage safety design with pu (p0) = 0.33 vs. pa (p1) = 0.20
  oc.gentwostage.bdry(0.33, 0.20, 8, 26, 22, 85)

  # Optimal two-stage efficacy design with pu (p0) = 0.67 vs. pa (p1) = 0.80
  oc.gentwostage.bdry(0.67, 0.80, 18, 26, 63, 85)
# }