genefu (version 2.4.2)

st.gallen: Function to compute the St Gallen consensus criterion for prognostication

Description

This function computes the updated St Gallen consensus criterions as published by Goldhirsh et al 2003.

Usage

st.gallen(size, grade, node, her2.neu, age, vascular.inv, na.rm = FALSE)

Arguments

size

tumor size in cm.

grade

Histological grade, i.e. low (1), intermediate (2) and high (3) grade.

node

Nodal status (0 or 1 for no lymph node invasion a,d at least 1 invaded lymph ode respectively).

her2.neu

Her2/neu status (0 or 1).

age

Age at diagnosis (in years).

vascular.inv

Peritumoral vascular invasion (0 or 1).

na.rm

TRUE if missing values should be removed, FALSE otherwise.

Value

• Vector of risk predictions: "Good", "Intermediate", and "Poor".

References

Goldhirsh A, Wood WC, Gelber RD, Coates AS, Thurlimann B, and Senn HJ (2003) "Meeting highlights: Updated international expert consensus on the primary therapy of early breast cancer", Journal of Clinical Oncology, 21(17):3357--3365.

See Also

npi

Examples

## load NKI dataset
data(NKI)
## compute St Gallen predictions
st.gallen(size=demo.nkis[ ,"size"], grade=demo.nkis[ ,"grade"],
  node=demo.nkis[ ,"node"], her2.neu=sample(x=0:1, size=nrow(demo.nkis),
  replace=TRUE), age=demo.nkis[ ,"age"], vascular.inv=sample(x=0:1,
  size=nrow(demo.nkis), replace=TRUE), na.rm=TRUE)