PieceR

This creates a RCurve object for a piecewise-linear recruitment distribution. 
RCurve objects contain all necessary information to describe a recruitment distribution. They are a particular type of Curve object containing additional recruitment-related information, including patient numbers and the randomisation ratio.

Provides tools to assist planning and monitoring of time-to-event trials under complicated censoring assumptions and/or non-proportional hazards. There are three main components: The first is analytic calculation of predicted time-to-event trial properties, providing estimates of expected hazard ratio, event numbers and power under different analysis methods. The second is simulation, allowing stochastic estimation of these same properties. Thirdly, it provides parametric event prediction using blinded trial data, including creation of prediction intervals. Methods are based upon numerical integration and a flexible object-orientated structure for defining event, censoring and recruitment distributions (Curves).

James Bell

gestate

Generalised Survival Trial Assessment Tool Environment

Jasmin Ruehl

PieceR function

<dl><dt>recruitment</dt>
<dd>2-column matrix with recruitment parameters. First column gives the lengths of each period of recruitment. Second column gives the corresponding rates of recruitment for each period.</dd>
<dt>ratio</dt>
<dd>Randomisation ratio; active arm divided by control arm.</dd></dl>

Arguments

Author

This creates a RCurve object for a piecewise-linear recruitment distribution. 
RCurve objects contain all necessary information to describe a recruitment distribution. They are a particular type of Curve object containing additional recruitment-related information, including patient numbers and the randomisation ratio.

PieceR RCurve constructor function — PieceR

<dl>

<dt>recruitment</dt>
<dd>2-column matrix with recruitment parameters. First column gives the lengths of each period of recruitment. Second column gives the corresponding rates of recruitment for each period.</dd>


<dt>ratio</dt>
<dd>Randomisation ratio; active arm divided by control arm.</dd>

</dl>

PieceR: PieceR RCurve constructor function

Description

Usage

Arguments

Author

Details

Examples