# \donttest{
rm(list=ls())
data(PBC)
# Compare quadratic vs linear time specification for log(serum bilirubin) -----
PBC$serBilir <- log(PBC$serBilir)
long.formulas1 <- list(serBilir ~ drug * time + (1 + time|id))
long.formulas2 <- list(serBilir ~ drug * (time + I(time^2)) + (1 + time + I(time^2)|id))
surv.formula <- Surv(survtime, status) ~ drug
family <- list('gaussian')
# Fit the two competing models (fit is nested in fit2) ------------------------
fit <- joint(long.formulas1, surv.formula, PBC, family,
control = list(verbose = FALSE))
fit2 <- joint(long.formulas2, surv.formula, PBC, family, control = list(verbose = FALSE))
anova(fit, fit2)
# Quadratic terms improve fit significantly.
# }
Run the code above in your browser using DataLab