grantham

grantham-package

A minimal set of routines to calculate the Grantham distance tools:::Rd_expr_doi("10.1126/science.185.4154.862"). The Grantham distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.

internal

A minimal set of routines to calculate the Grantham distance
<doi:10.1126/science.185.4154.862>. The Grantham distance attempts to
provide a proxy for the evolutionary distance between two amino acids
based on three key chemical properties: composition, polarity and
molecular volume. In turn, evolutionary distance is used as a proxy for
the impact of missense mutations. The higher the distance, the more
deleterious the substitution is expected to be.

Ramiro Magno

Calculate the Grantham Distance

Isabel Duarte

Ana-Teresa Maia

University of Algarve 

CINTESIS 

Pattern Institute 

grantham-package function

Maintainer: Ramiro Magno <a href="/link/rmagno%40pattern.institute?package=grantham&version=0.1.2" data-mini-rdoc="grantham::rmagno@pattern.institute">rmagno@pattern.institute</a> (<a href="https://orcid.org/0000-0001-5226-3441">ORCID</a>)
Authors:<ul>
<li>Isabel Duarte <a href="/link/iduarte%40pattern.institute?package=grantham&version=0.1.2" data-mini-rdoc="grantham::iduarte@pattern.institute">iduarte@pattern.institute</a> (<a href="https://orcid.org/0000-0003-0060-2936">ORCID</a>)</li>
<li>Ana-Teresa Maia <a href="/link/maia.anateresa%40gmail.com?package=grantham&version=0.1.2" data-mini-rdoc="grantham::maia.anateresa@gmail.com">maia.anateresa@gmail.com</a> (<a href="https://orcid.org/0000-0002-0454-9207">ORCID</a>)</li>
</ul>Other contributors:<ul>
<li>University of Algarve [funder]</li>
<li>CINTESIS [funder]</li>
<li>Pattern Institute [copyright holder, funder]</li>
</ul>

Author

grantham: Calculate the Grantham Distance — grantham-package

Maintainer: Ramiro Magno <a href='mailto:rmagno@pattern.institute'>rmagno@pattern.institute</a> (<a href='https://orcid.org/0000-0001-5226-3441'>ORCID</a>)
Authors:<ul>
<li>Isabel Duarte <a href='mailto:iduarte@pattern.institute'>iduarte@pattern.institute</a> (<a href='https://orcid.org/0000-0003-0060-2936'>ORCID</a>)</li>
<li>Ana-Teresa Maia <a href='mailto:maia.anateresa@gmail.com'>maia.anateresa@gmail.com</a> (<a href='https://orcid.org/0000-0002-0454-9207'>ORCID</a>)</li>
</ul>

Other contributors:<ul>
<li>University of Algarve [funder]</li>
<li>CINTESIS [funder]</li>
<li>Pattern Institute [copyright holder, funder]</li>
</ul>

grantham-package: grantham: Calculate the Grantham Distance

Description

Arguments

Author

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