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grmsem (version 1.1.0)

Genetic-Relationship-Matrix Structural Equation Modelling (GRMSEM)

Description

Quantitative genetics tool supporting the modelling of multivariate genetic variance structures in quantitative data. It allows fitting different models through multivariate genetic-relationship-matrix (GRM) structural equation modelling (SEM) in unrelated individuals, using a maximum likelihood approach. Specifically, it combines genome-wide genotyping information, as captured by GRMs, with twin-research-based SEM techniques, St Pourcain et al. (2017) , Shapland et al. (2020) .

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Version

Install

install.packages('grmsem')

Monthly Downloads

181

Version

1.1.0

License

GPL-3

Maintainer

Beate StPourcain

Last Published

January 29th, 2021

Functions in grmsem (1.1.0)

fit.large

Prefitted model: large data set
ph.small

Phenotype data: small data set
ph.large

Phenotype data: large data set
grm.bin.input

grm import function
grmsem.fcoher

grmsem factorial co-heritability and co-environmentality estimation function.
G.small

Symmetric GRM data: small data set
grmsem.biher

grmsem bivariate heritability estimation function.
grm.input

grm import function
grmsem.var

grmsem variance estimation function
grmsem.fit

grmsem model fitting function
grmsem.stpar

grmsem standardised parameters function