gsDesignNB (version 0.2.6)

compute_info_at_time: Compute statistical information at analysis time

Description

Computes the statistical information for the log rate ratio at a given analysis time, accounting for staggered enrollment and varying exposure times.

Usage

compute_info_at_time(
  analysis_time,
  accrual_rate,
  accrual_duration,
  lambda1,
  lambda2,
  dispersion,
  ratio = 1,
  dropout_rate = 0,
  event_gap = 0,
  max_followup = Inf
)

Value

The statistical information (inverse of variance) at the analysis time.

Arguments

analysis_time

The calendar time of the analysis.

accrual_rate

The enrollment rate (subjects per time unit).

accrual_duration

The duration of the enrollment period.

lambda1

Event rate for group 1 (control).

lambda2

Event rate for group 2 (treatment).

dispersion

The negative binomial dispersion parameter.

ratio

Allocation ratio (n2/n1). Default is 1.

dropout_rate

Dropout rate (hazard rate). Default is 0.

event_gap

Gap duration after each event during which no new events are counted. Default is 0.

max_followup

Maximum follow-up time per subject. Exposure time is truncated at this value. Default is Inf (no truncation).

Examples

compute_info_at_time(
  analysis_time = 12,
  accrual_rate = 10,
  accrual_duration = 10,
  lambda1 = 0.5,
  lambda2 = 0.3,
  dispersion = 0.1
)