height.scores

Risk score for height parameterised using GWAS meta-analysis results
  published by Lango Allen et al. (Nature 2010) as part of work by the
  GIANT consortium.

datasets

Assorted tools for genetic association analyses.  The focus is on implementing (either exactly or approximately) regression analyses using summary statistics instead of using subject-specific data.  So far, functions exist to support multi-SNP risk score analyses, and multi-SNP conditional regression analyses, using summary statistics.  There are helper functions for reading and manipulating subject-specific genotype data, which provide a platform for calculating the summary statistics, or for using R to conduct other analyses not supported by specific GWAS analysis tools.

Toby Johnson

Genetics ToolboX

height.scores function

A data frame suitable for use with other functions in this package,
 see <a href="/link/gtx.params?package=gtx&version=0.0.3" rd-options="" data-mini-rdoc="gtx::gtx.params">gtx.params</a>. The score is called HEIGHT2010, and has coefficients in height Z score
 units (i.e. phenotypic standard deviations) per coded
 allele. One phenotypic standard deviation for height is 0.06-0.07m in
 most samples analysed by Lango Allen et al. Effect size estimates are taken from the <dquote>STAGE 2</dquote> results in
 Supplementary Table 1 of Lango Allen et al.

format

For the publication by Lango Allen et al. from which these data were extracted see <url>http://dx.doi.org/10.1038/nature09410</url>.

height.scores: Genetic risk score for height.

Description

Usage

Arguments

format

source