KHCE

A dataset with kidney ordinal scale outcomes of 1500 patients in the <code>ADSL</code> dataset.

datasets

Simulate and analyze hierarchical composite endpoints. Win odds is the main analysis method, but other win statistics (win ratio, net benefit) are also implemented, provided there is no censoring. See Gasparyan SB et al (2023) "Hierarchical Composite Endpoints in COVID-19: The DARE-19 Trial." Case Studies in Innovative Clinical Trials, 95-148. Chapman; Hall/CRC. <doi:10.1201/9781003288640-7>.

Samvel B. Gasparyan

Design and Analysis of Hierarchical Composite Endpoints

KHCE function

a data frame with 1500 rows and 11 variables:<dl>
<dt>ID</dt>
<dd>patient identifiers, numeric</dd><dt>TRTPN</dt>
<dd>treatment values, 1 Active or 2 Placebo, numeric</dd><dt>AVAL0</dt>
<dd>original values for each type of the event, time for TTE outcomes 1-6, numeric values for Continuous outcome 7, numeric</dd><dt>AVAL</dt>
<dd><code>AVAL = AVAL0 + GROUPN</code>, ordinal analysis values for the HCE analysis, numeric, but caution NOT to apply numeric operations; will give meaningless results</dd><dt>GROUP</dt>
<dd>name of the event, character</dd><dt>GROUPN</dt>
<dd>ordinal outcomes corresponding to <code>PARAMN</code> values, numeric</dd><dt>PARAMCD</dt>
<dd>coded name of the event, character</dd><dt>PARAMN</dt>
<dd>severity of the event, outcomes 1-7, where a higher value means a better outcome, character</dd><dt>STRATAN</dt>
<dd>strata 1-4, higher value means more severe kidney disease, numeric</dd><dt>EGFRBL</dt>
<dd>Baseline GFR values of patients, numeric</dd><dt>TRTP</dt>
<dd>treatment values, A Active or P Placebo, character</dd><dt>PADY</dt>
<dd>primary analysis day (in years), length of the fixed follow-up, numeric</dd>
</dl>

Format

Kidney Hierarchical Composite Endpoint dataset. — KHCE

a data frame with 1500 rows and 11 variables:<dl>
<dt>ID</dt>
<dd>patient identifiers, numeric</dd>

<dt>TRTPN</dt>
<dd>treatment values, 1 Active or 2 Placebo, numeric</dd>

<dt>AVAL0</dt>
<dd>original values for each type of the event, time for TTE outcomes 1-6, numeric values for Continuous outcome 7, numeric</dd>

<dt>AVAL</dt>
<dd><code>AVAL = AVAL0 + GROUPN</code>, ordinal analysis values for the HCE analysis, numeric, but caution NOT to apply numeric operations; will give meaningless results</dd>

<dt>GROUP</dt>
<dd>name of the event, character</dd>

<dt>GROUPN</dt>
<dd>ordinal outcomes corresponding to <code>PARAMN</code> values, numeric</dd>

<dt>PARAMCD</dt>
<dd>coded name of the event, character</dd>

<dt>PARAMN</dt>
<dd>severity of the event, outcomes 1-7, where a higher value means a better outcome, character</dd>

<dt>STRATAN</dt>
<dd>strata 1-4, higher value means more severe kidney disease, numeric</dd>

<dt>EGFRBL</dt>
<dd>Baseline GFR values of patients, numeric</dd>

<dt>TRTP</dt>
<dd>treatment values, A Active or P Placebo, character</dd>

<dt>PADY</dt>
<dd>primary analysis day (in years), length of the fixed follow-up, numeric</dd>


</dl>

KHCE: Kidney Hierarchical Composite Endpoint dataset.

Description

Usage

Arguments

Format

Examples