Multiple sclerosis lesion counts for three patients.
Lesion counts for three multiple sclerosis patients. The counts were obtained by magnetic resonance imaging, and were observed at monthly intervals.
A list with three components each component being the sequence of counts for a given patient and consisting of a vector with non-negative integer entries.
The hidden Markov models applied to these data by Albert et al. and by MacKay and Petkau were much more complex and elaborate than those fitted in the examples in this package. See the references for details.
Albert, P. S., McFarland, H. F., Smith, M. E., and Frank, J. A. Time series for modelling counts from a relapsing-remitting disease: application to modelling disease activity in multiple sclerosis. Statistics in Medicine 13 (1994) 453--466.
Altman, Rachel MacKay, and Petkau, A. John. Application of hidden Markov models to multiple sclerosis lesion count data. Statistics in Medicine 24 (2005) 2335--2344.