karlin

Calculation of genetic distances from recombination rates given
 a parameter

Paternal recombination rate and maternal linkage disequilibrium
(LD) are estimated for pairs of biallelic markers such as single nucleotide
polymorphisms (SNPs) from progeny genotypes and sire haplotypes. The
implementation relies on paternal half-sib families. If maternal half-sib
families are used, the roles of sire/dam are swapped. Multiple families can
be considered. For parameter estimation, at least one sire has to be double
heterozygous at the investigated pairs of SNPs.
Based on recombination rates, genetic distances between markers can be
estimated. Markers with unusually large recombination rate to markers in
close proximity (i.e. putatively misplaced markers) shall be discarded in
this derivation.
A workflow description is attached as vignette.
*A pipeline is available at GitHub*
<https://github.com/wittenburg/hsrecombi>
Hampel, Teuscher, Gomez-Raya, Doschoris, Wittenburg (2018) "Estimation of
recombination rate and maternal linkage disequilibrium in half-sibs"
<doi:10.3389/fgene.2018.00186>.
Gomez-Raya (2012) "Maximum likelihood estimation of linkage disequilibrium
in half-sib families" <doi:10.1534/genetics.111.137521>.

D<c3><b6>rte Wittenburg

hsrecombi

Estimation of Recombination Rate and Maternal LD in Half-Sibs

Dörte Wittenburg

karlin function

<dl><dt>N</dt>
<dd>parameter (positive integer) required by the binomial model to
assess the count (of crossover) distribution; <code>N = 1</code> corresponds to
Morgan's map function</dd>
<dt>x</dt>
<dd>vector of recombination rates</dd>
<dt>inverse</dt>
<dd>logical, if FALSE recombination rate is mapped to Morgan unit,
if TRUE Morgan unit is mapped to recombination rate (default is FALSE)</dd></dl>

Arguments

Liberman and Karlin's genetic map function — karlin

<dl>

<dt>N</dt>
<dd>parameter (positive integer) required by the binomial model to
assess the count (of crossover) distribution; <code>N = 1</code> corresponds to
Morgan's map function</dd>


<dt>x</dt>
<dd>vector of recombination rates</dd>


<dt>inverse</dt>
<dd>logical, if FALSE recombination rate is mapped to Morgan unit,
if TRUE Morgan unit is mapped to recombination rate (default is FALSE)</dd>

</dl>

karlin: Liberman and Karlin's genetic map function

Description

Usage

Value

Arguments

References

Examples