httk (version 1.3)

calc_elimination_rate: Calculate the elimination rate for a one compartment model.

Description

This function calculates an elimination rate from the three compartment steady state model where elimination is entirely due to metablism by the liver and glomerular filtration in the kidneys.

Usage

calc_elimination_rate(chem.cas=NULL,chem.name=NULL,parameters=NULL,species="Human",
                      suppress.messages=F,default.to.human=F)

Arguments

chem.name

Either the chemical name or the cas number must be specified.

chem.cas

Either the cas number or the chemical name must be specified.

parameters

Chemical parameters from parameterize_steadystate or 1compartment function, overrides chem.name and chem.cas.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

suppress.messages

Whether or not the output message is suppressed.

default.to.human

Substitutes missing animal values with human values if true.

Value

• Elimination rate
  Units of 1/h.

Details

When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.

Examples

calc_elimination_rate(chem.name="Bisphenol A")
calc_elimination_rate(chem.name="Bisphenol A",species="Rat")
calc_elimination_rate(chem.name="Bisphenol A",species="Rabbit")
calc_elimination_rate(chem.cas="80-05-7")