httk (version 1.3)

calc_mc_oral_equiv: Calculate Monte Carlo Oral Equivalent Dose

Description

This functions converts a chemical plasma concetration to an oral equivalent dose using a concentration obtained from calc_mc_css.

Usage

calc_mc_oral_equiv(conc,chem.name=NULL,chem.cas=NULL,which.quantile=0.95,
                   species="Human",input.units='uM',output.units='mg',
                   suppress.messages=F,return.samples=F,...)

Arguments

conc

Bioactive in vitro concentration in units of uM.

chem.name

Either the chemical name or the CAS number must be specified.

chem.cas

Either the CAS number or the chemical name must be specified.

suppress.messages

Suppress text messages.

input.units

Units of given concentration, default of uM but can also be mg/L.

output.units

Units of dose, default of 'mg' for mg/kg BW/ day or 'mol' for mol/ kg BW/ day.

which.quantile

Which quantile from Monte Carlo simulation is requested. Can be a vector.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

return.samples

Whether or not to return the vector containing the samples from the simulation instead of the selected quantile.

...

Additional parameters passed to calc_mc_css.

Value

• Equivalent dose in specified units, default of mg/kg BW/day.

Details

When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.

Examples

calc_mc_oral_equiv(0.1,chem.cas="34256-82-1")

calc_mc_oral_equiv(0.1,chem.cas="34256-82-1",which.quantile=c(0.05,0.5,0.95))