calc_rblood2plasma

Either the chemical name or the CAS number must be specified.

chem.name

Either the CAS number or the chemical name must be specified.

chem.cas

Substitutes missing animal values with human values if true.

default.to.human

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

species

This function calculates the constant ratio of the blood concentration to the plasma concentration. It uses the hematocrit and the red blood cell (RBC) parition coefficient as predicted by the Schmitt (2008) method.

Parameter

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

calc_rblood2plasma: Calculate the constant ratio of the blood concentration to the plasma concentration.

Description

Usage

Arguments

Details

References

Examples