Usage
calc_stats(days,chem.name=NULL,chem.cas=NULL,parameters=NULL,stats=c("AUC","peak","mean"),
species='Human',exclude.fub.zero=F,daily.dose=1,dose=NULL,doses.per.day=NULL,
output.units='uM',concentration='plasma',model='pbtk',suppress.messages=F,...)Arguments
days
Length of the simulation.
chem.name
Name of desired chemical.
chem.cas
CAS number of desired chemical.
parameters
Chemical parameters from parameterize_pbtk function, overrides chem.name and chem.cas.
stats
Desired values (either 'AUC', 'mean', 'peak', or a vector containing any combination).
daily.dose
Total daily dose, mg/kg BW.
dose
Amount of a single dose, mg/kg BW. Overwrites daily.dose.
species
Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").
exclude.fub.zero
Whether or not to exclude chemicals with a fraction of unbound plasma equal to zero or include them with a value of 0.005, only used when chem.name, chem.cas, and parameters are not specified.
doses.per.day
Number of doses per day.
output.units
Desired units (either "mg/L", "mg", "umol", or default "uM").
model
Model used in calculation, 'pbtk' for the multiple compartment model,'3compartment' for the three compartment model, '3compartmentss' for the three compartment steady state model, and '1compartment' for one compartment model.
concentration
Desired concentration type, 'blood' or default 'plasma'.
suppress.messages
Whether to suppress output message.
...
Arguments passed to solve function.