httk (version 1.3)

parameterize_1comp: Parameterize_1comp

Description

This function initializes the parameters needed in the function solve_1comp.

Usage

parameterize_1comp(chem.cas=NULL,chem.name=NULL,species="Human",
                    default.to.human=F)

Arguments

chem.name

Either the chemical name or the CAS number must be specified.

chem.cas

Either the chemical name or the CAS number must be specified.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

default.to.human

Substitutes missing rat values with human values if true.

Value

• Vdist
  Volume of distribution, units of L/kg BW.
• Fgutabs
  Fraction of the oral dose absorbed, i.e. the fraction of the dose that enters the gutlumen.
• kelim
  Elimination rate, units of 1/h.
• hematocrit
  Percent volume of red blood cells in the blood.
• kgutabs
  Rate chemical is absorbed, 1/h.
• million.cells.per.gliver
  Millions cells per gram of liver tissue.
• MW
  Molecular Weight, g/mol.
• Rblood2plasma
  The ratio of the concentration of the chemical in the blood to the concentration in the plasma.

Details

When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.

Examples

parameters <- parameterize_1comp(chem.name='Bisphenol-A',species='Rat')
 parameters <- parameterize_1comp(chem.cas='80-05-7')