tissue.data

This data set contains values from Schmitt (2008) describing the composition
of specific tissues and from Birnbaum et al. (1994) describing
volumes of and blood flows to those tissues, allowing parameterization of 
toxicokinetic models for human, mouse, rat, dog, or rabbit.

datasets

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

tissue.data: Tissue composition and species-specific physiology parameters

Description

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References