calc_total_clearance

Either the chemical name, CAS number, or the parameters must be specified.

chem.name

chem.cas

Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas.

parameters

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

species

Whether or not the output message is suppressed.

suppress.messages


  Substitutes missing animal values with human values if true.
  

default.to.human

This function calculates the total clearance rate for a one compartment model where 
clearance is entirely due to metablism by the liver and glomerular filtration in the kidneys, identical to clearance of three compartment steady state model.

Parameter

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

calc_total_clearance: Calculate the total clearance.

Description

Usage

Arguments

Value

Details

Examples