httk (version 1.6)

calc_hepatic_clearance: Calculate the hepatic clearance.

Description

This function calculates the hepatic clearance in plasma for a well-stirred model or other type if specified.

Usage

calc_hepatic_clearance(chem.name=NULL,chem.cas=NULL,parameters=NULL,
                       species='Human',default.to.human=F,
                       hepatic.model='well-stirred',
                       suppress.messages=F,well.stirred.correction=T,
                       restrictive.clearance=T,Funbound.plasma.pc.correction=T,...)

Arguments

chem.name

Either the chemical name, CAS number, or the parameters must be specified.

chem.cas

Either the chemical name, CAS number, or the parameters must be specified.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

default.to.human

Substitutes missing animal values with human values if true.

parameters

Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas.

hepatic.model

Model used in calculating hepatic clearance, unscaled, parallel tube, dispersion, or default well-stirred.

suppress.messages

Whether or not to suppress the output message.

well.stirred.correction

Uses correction in calculation of hepatic clearance for well-stirred model if TRUE for hepatic.model well-stirred. This assumes clearance relative to amount unbound in whole blood instead of plasma, but converted to use with plasma concentration.

restrictive.clearance

Protein binding not taken into account (set to 1) in liver clearance if FALSE.

Funbound.plasma.pc.correction

Uses corrected Funbound.plasma when set to TRUE along with parition coefficients calculated with this value and regressions. Only applies to calculation of Rblood2plasma in well-stirred correction when in vivo Rblood2plasma is unavailable.

...

Additional parameters passed to parameterize_steadystate if parameters is NULL.

Value

Hepatic Clearance

Units of L/h/kg BW.

Examples

# NOT RUN {
calc_hepatic_clearance(chem.name="Ibuprofen",hepatic.model='unscaled')
calc_hepatic_clearance(chem.name="Ibuprofen",well.stirred.correction=FALSE)

# }