convert_httk

A data.table containing the physiological
parameters as expected by HTTK (from <code><a rd-options="" href="/link/httkpop_bio?package=httk&version=1.6" data-mini-rdoc="httk::httkpop_bio">httkpop_bio</a></code>) and
<code>Funbound.plasma</code> and <code>Clint</code> values (from
<code><a rd-options="" href="/link/draw_fup_clint?package=httk&version=1.6" data-mini-rdoc="httk::draw_fup_clint">draw_fup_clint</a></code>).

indiv.model.bio

Which HTTK model to use. One of '1compartment', '3compartmentss',
'3compartment', or 'pbtk'.

model

CAS number for the chemical in the HTTK data set for which 
parameters are to be generated.

this.chem

Uses regressions in calculating partition coefficients if TRUE.

Funbound.plasma.pc.correction

Uses correction in calculation of hepatic clearance for well-stirred model if TRUE for model 1compartment elimination rate. 
 This assumes clearance relative to amount unbound in whole blood instead of plasma, but converted to use with plasma concentration.

well.stirred.correction

Protein binding not taken into account (set to 1) in liver clearance if FALSE for model 1compartment elimination rate.

restrictive.clearance

Converts HTTK-Pop virtual population into parameters relevant to an HTTK 
model.

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

John Wambaugh

httk

High-Throughput Toxicokinetics

convert_httk function

A data.table containing the physiological
parameters as expected by HTTK (from <code><a rd-options='' href='httkpop_bio'>httkpop_bio</a></code>) and
<code>Funbound.plasma</code> and <code>Clint</code> values (from
<code><a rd-options='' href='draw_fup_clint'>draw_fup_clint</a></code>).

convert_httk: Converts HTTK-Pop virtual population into parameters relevant to an HTTK model.

Description

Usage

Arguments

Value