httkpop

httkpop-package

The httkpop package generates virtual population physiologies for use in 
population TK.

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

John Wambaugh

httk

High-Throughput Toxicokinetics

httkpop function

If you just want to generate
 a table of (chemical-independent) population physiology parameters, use 
 <code><a rd-options="" href="/link/httkpop_generate?package=httk&version=1.6" data-mini-rdoc="httk::httkpop_generate">httkpop_generate</a></code>.

Main function to generate a population

To generate a population and then run an 
 HTTK model for that population, the workflow is as follows:<ol>
<li>Generate a population using <code><a rd-options="" href="/link/httkpop_generate?package=httk&version=1.6" data-mini-rdoc="httk::httkpop_generate">httkpop_generate</a></code>.</li>
<li>For
 a given HTTK chemical and general model, convert the population data to 
 corresponding sets of HTTK model parameters using 
 <code><a rd-options="" href="/link/get_httk_params?package=httk&version=1.6" data-mini-rdoc="httk::get_httk_params">get_httk_params</a></code>.</li>
</ol>

httkpop: httkpop: Virtual population generator for HTTK.

Description

Arguments

Main function to generate a population

Using HTTK-Pop with HTTK