aylward2014

Aylward2014

<p>Aylward et al. (2014) compiled measurements of the ratio of maternal to fetal 
cord blood chemical concentrations at birth for a range of chemicals with 
environmental routes of exposure, including bromodiphenyl ethers, fluorinated 
compounds, organochlorine pesticides, polyaromatic hydrocarbons, tobacco smoke 
components, and vitamins.</p>
<p>Aylward et al. (2014) compiled measurements of the ratio of maternal to fetal 
cord blood chemical concentrations at birth for a range of chemicals with 
environmental routes of exposure, including bromodiphenyl ethers, fluorinated 
compounds, organochlorine pesticides, polyaromatic hydrocarbons, tobacco smoke 
components, and vitamins.</p>

data

High throughput toxicokinetics ("HTTK") is the
combination of 1) chemical-specific in vitro measurements or in
silico predictions and 2) generic mathematical models, to
predict absorption, distribution, metabolism, and excretion by the
body. HTTK methods have been described by Pearce et al. (2017)
(<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>).
Here we provide examples (vignettes) applying HTTK to solve various
problems in bioinformatics, toxicology, and exposure science.
In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>),
whenever a new HTTK model is developed, the code to generate the
figures evaluating that model is added as a new vignettte.

John Wambaugh

httkexamples

High-Throughput Toxicokinetics Examples

Robert Pearce

Caroline Ring

Greg Honda

Matt Linakis

Dustin Kapraun

Kimberly Truong

Meredith Scherer

Annabel Meade

Celia Schacht

Elaina Kenyon

aylward2014 function

Format

Aylward et al. 2014 — aylward2014

Aylward et al. 2014

aylward2014: Aylward et al. 2014

Description

Usage

Arguments

Format

References