dermal.toxcast

<p>Chemicals with ToxCast data for Meade et al. (submitted) chemicals
Meade et al. (submitted) performed in vitro-in vivo extrapolation for 
dermal exposures assuming 8 hours of exposure via hands submerged in a
liquid with 1 ppm of chemical. These are the ToxCast in vitro screening
data for those chemicals.</p>

data

High throughput toxicokinetics ("HTTK") is the
combination of 1) chemical-specific in vitro measurements or in
silico predictions and 2) generic mathematical models, to
predict absorption, distribution, metabolism, and excretion by the
body. HTTK methods have been described by Pearce et al. (2017)
(<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>).
Here we provide examples (vignettes) applying HTTK to solve various
problems in bioinformatics, toxicology, and exposure science.
In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>),
whenever a new HTTK model is developed, the code to generate the
figures evaluating that model is added as a new vignettte.

John Wambaugh

httkexamples

High-Throughput Toxicokinetics Examples

Robert Pearce

Caroline Ring

Greg Honda

Matt Linakis

Dustin Kapraun

Kimberly Truong

Meredith Scherer

Annabel Meade

Celia Schacht

Elaina Kenyon

dermal.toxcast function

Format

Chemicals with ToxCast data for Meade et al. (submitted) chemicals
Meade et al. (submitted) performed in vitro-in vivo extrapolation for 
dermal exposures assuming 8 hours of exposure via hands submerged in a
liquid with 1 ppm of chemical. These are the ToxCast in vitro screening
data for those chemicals. — dermal.toxcast

Chemicals with ToxCast data for Meade et al. (submitted) chemicals
Meade et al. (submitted) performed in vitro-in vivo extrapolation for 
dermal exposures assuming 8 hours of exposure via hands submerged in a
liquid with 1 ppm of chemical. These are the ToxCast in vitro screening
data for those chemicals.

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