dermalCvT2025

<p>Toxicokinetic concentration vs. time (CvT) data for Meade et al. (submitted) chemicals
Meade et al. (submitted) evaluated a generic PBTK model for dermal exposure
using in vivo CvT data curated from the literature. These data will
eventually be incorporated in the the CvTdb (Sayre et al., 2020, tools:::Rd_expr_doi("10.1038/s41597-020-0455-1")).</p>

data

High throughput toxicokinetics ("HTTK") is the
combination of 1) chemical-specific in vitro measurements or in
silico predictions and 2) generic mathematical models, to
predict absorption, distribution, metabolism, and excretion by the
body. HTTK methods have been described by Pearce et al. (2017)
(<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>).
Here we provide examples (vignettes) applying HTTK to solve various
problems in bioinformatics, toxicology, and exposure science.
In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>),
whenever a new HTTK model is developed, the code to generate the
figures evaluating that model is added as a new vignettte.

John Wambaugh

httkexamples

High-Throughput Toxicokinetics Examples

Robert Pearce

Caroline Ring

Greg Honda

Matt Linakis

Dustin Kapraun

Kimberly Truong

Meredith Scherer

Annabel Meade

Celia Schacht

Elaina Kenyon

dermalCvT2025 function

Format

Toxicokinetic concentration vs. time (CvT) data for Meade et al. (submitted) chemicals
Meade et al. (submitted) evaluated a generic PBTK model for dermal exposure
using in vivo CvT data curated from the literature. These data will
eventually be incorporated in the the CvTdb (Sayre et al., 2020, tools:::Rd_expr_doi("10.1038/s41597-020-0455-1")). — dermalCvT2025

Toxicokinetic concentration vs. time (CvT) data for Meade et al. (submitted) chemicals
Meade et al. (submitted) evaluated a generic PBTK model for dermal exposure
using in vivo CvT data curated from the literature. These data will
eventually be incorporated in the the CvTdb (Sayre et al., 2020, tools:::Rd_expr_doi("10.1038/s41597-020-0455-1")).

Description

Usage

Arguments

Format

References