High throughput toxicokinetics ("HTTK") is the combination of 1) chemical-specific in vitro measurements or in silico predictions and 2) generic mathematical models, to predict absorption, distribution, metabolism, and excretion by the body. HTTK methods have been described by Pearce et al. (2017) (tools:::Rd_expr_doi("10.18637/jss.v079.i04")) and Breen et al. (2021) (tools:::Rd_expr_doi("10.1080/17425255.2021.1935867")). Here we provide examples (vignettes) applying HTTK to solve various problems in bioinformatics, toxicology, and exposure science. In accordance with Davidson-Fritz et al. (2025) (tools:::Rd_expr_doi("10.1371/journal.pone.0321321")), whenever a new HTTK model is developed, the code to generate the figures evaluating that model is added as a new vignettte.
Maintainer: John Wambaugh john.wambaugh@UL.org (ORCID)
Authors:
Robert Pearce (ORCID)
Caroline Ring Ring.Caroline@epa.gov (ORCID)
Greg Honda honda.gregory@epa.gov (ORCID)
Matt Linakis MLINAKIS@ramboll.com (ORCID)
Dustin Kapraun kapraun.dustin@epa.gov (ORCID)
Kimberly Truong truong.kimberly@epa.gov (ORCID)
Meredith Scherer Scherer.Meredith@epa.gov (ORCID)
Annabel Meade aemeade7@gmail.com (ORCID)
Celia Schacht Schacht.Celia@epa.gov (ORCID)
Other contributors:
Elaina Kenyon (ORCID) [contributor]
Useful links: