meade2025

Meade2025

<p>Simulation outputs from Meade et al. (submitted)
Meade et al. (submitted) performed generic PBTK simulations for dermal
exposure under a variety of assumptions. Although the code to recreate these
simulations is provided, it is time-intensive. The 2025 outputs from the 
simulations are stored in this list of data.frames.</p>

data

High throughput toxicokinetics ("HTTK") is the
combination of 1) chemical-specific in vitro measurements or in
silico predictions and 2) generic mathematical models, to
predict absorption, distribution, metabolism, and excretion by the
body. HTTK methods have been described by Pearce et al. (2017)
(<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>).
Here we provide examples (vignettes) applying HTTK to solve various
problems in bioinformatics, toxicology, and exposure science.
In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>),
whenever a new HTTK model is developed, the code to generate the
figures evaluating that model is added as a new vignettte.

John Wambaugh

httkexamples

High-Throughput Toxicokinetics Examples

Robert Pearce

Caroline Ring

Greg Honda

Matt Linakis

Dustin Kapraun

Kimberly Truong

Meredith Scherer

Annabel Meade

Celia Schacht

Elaina Kenyon

meade2025 function

Format

Simulation outputs from Meade et al. (submitted)
Meade et al. (submitted) performed generic PBTK simulations for dermal
exposure under a variety of assumptions. Although the code to recreate these
simulations is provided, it is time-intensive. The 2025 outputs from the 
simulations are stored in this list of data.frames. — meade2025

Simulation outputs from Meade et al. (submitted)
Meade et al. (submitted) performed generic PBTK simulations for dermal
exposure under a variety of assumptions. Although the code to recreate these
simulations is provided, it is time-intensive. The 2025 outputs from the 
simulations are stored in this list of data.frames.

Description

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References