Measured rat in vivo partition coefficients and data for predicting them.
Measured rat in vivo partition coefficients and data for predicting them.
pc.datapc.data
A data.frame.
A data.frame.
Jimena Davis and Robert Pearce
schmitt2008generalhttkexamples
schmitt2008corrigendumhttkexamples
Poulin, P. and F.P. Theil, A priori prediction of tissue: plasma partition coefficients of drugs to facilitate the use of physiologically based pharmacokinetic models in drug discovery. Journal of pharmaceutical sciences, 2000. 89(1): p. 16-35.
Rodgers, T. and M. Rowland, Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. Journal of pharmaceutical sciences, 2006. 95(6): p. 1238-1257.
Rodgers, T., D. Leahy, and M. Rowland, Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. Journal of pharmaceutical sciences, 2005. 94(6): p. 1259-1276.
Rodgers, T., D. Leahy, and M. Rowland, Tissue distribution of basic drugs: Accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. Journal of pharmaceutical sciences, 2005. 94(6): p. 1237-1248.
Gueorguieva, I., et al., Development of a whole body physiologically based model to characterise the pharmacokinetics of benzodiazepines. 1: Estimation of rat tissue-plasma partition ratios. Journal of pharmacokinetics and pharmacodynamics, 2004. 31(4): p. 269-298.
Poulin, P., K. Schoenlein, and F.P. Theil, Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs. Journal of pharmaceutical sciences, 2001. 90(4): p. 436-447.
Bjorkman, S., Prediction of the volume of distribution of a drug: which tissue-plasma partition coefficients are needed? Journal of pharmacy and pharmacology, 2002. 54(9): p. 1237-1245.
yun2013correlationhttkexamples
Uchimura, T., et al., Prediction of human blood-to-plasma drug concentration ratio. Biopharmaceutics & drug disposition, 2010. 31(5-6): p. 286-297.
schmitt2008generalhttkexamples
schmitt2008corrigendumhttkexamples
Poulin, P. and F.P. Theil, A priori prediction of tissue: plasma partition coefficients of drugs to facilitate the use of physiologically based pharmacokinetic models in drug discovery. Journal of pharmaceutical sciences, 2000. 89(1): p. 16-35.
Rodgers, T. and M. Rowland, Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. Journal of pharmaceutical sciences, 2006. 95(6): p. 1238-1257.
Rodgers, T., D. Leahy, and M. Rowland, Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. Journal of pharmaceutical sciences, 2005. 94(6): p. 1259-1276.
Rodgers, T., D. Leahy, and M. Rowland, Tissue distribution of basic drugs: Accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. Journal of pharmaceutical sciences, 2005. 94(6): p. 1237-1248.
Gueorguieva, I., et al., Development of a whole body physiologically based model to characterise the pharmacokinetics of benzodiazepines. 1: Estimation of rat tissue-plasma partition ratios. Journal of pharmacokinetics and pharmacodynamics, 2004. 31(4): p. 269-298.
Poulin, P., K. Schoenlein, and F.P. Theil, Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs. Journal of pharmaceutical sciences, 2001. 90(4): p. 436-447.
Bjorkman, S., Prediction of the volume of distribution of a drug: which tissue-plasma partition coefficients are needed? Journal of pharmacy and pharmacology, 2002. 54(9): p. 1237-1245.
yun2013correlationhttkexamples
Uchimura, T., et al., Prediction of human blood-to-plasma drug concentration ratio. Biopharmaceutics & drug disposition, 2010. 31(5-6): p. 286-297.