pregnonpregaucs

<p>Dallmann et al. (2018) includes compiled literature descriptions of 
toxicokinetic summary statistics, including time-integrated plasma 
concentrations (area under the curve or AUC) for drugs administered to a 
sample of subjects including both pregnant and non-pregnant women. The 
circumstances of the dosing varied slightly between drugs and are summarized 
in the table.</p>
<p>Dallmann et al. (2018) includes compiled literature descriptions of 
toxicokinetic summary statistics, including time-integrated plasma 
concentrations (area under the curve or AUC) for drugs administered to a 
sample of subjects including both pregnant and non-pregnant women. The 
circumstances of the dosing varied slightly between drugs and are summarized 
in the table.</p>

data

High throughput toxicokinetics ("HTTK") is the
combination of 1) chemical-specific in vitro measurements or in
silico predictions and 2) generic mathematical models, to
predict absorption, distribution, metabolism, and excretion by the
body. HTTK methods have been described by Pearce et al. (2017)
(<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>).
Here we provide examples (vignettes) applying HTTK to solve various
problems in bioinformatics, toxicology, and exposure science.
In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>),
whenever a new HTTK model is developed, the code to generate the
figures evaluating that model is added as a new vignettte.

John Wambaugh

httkexamples

High-Throughput Toxicokinetics Examples

Robert Pearce

Caroline Ring

Greg Honda

Matt Linakis

Dustin Kapraun

Kimberly Truong

Meredith Scherer

Annabel Meade

Celia Schacht

Elaina Kenyon

pregnonpregaucs function

Format

AUCs for Pregnant and Non-Pregnant Women — pregnonpregaucs

AUCs for Pregnant and Non-Pregnant Women

pregnonpregaucs: AUCs for Pregnant and Non-Pregnant Women

Description

Usage

Arguments

Format

References