wallis2023

Wallis2023

<p>Wallis et al. 2023
Wallis et al. (2023) (tools:::Rd_expr_doi("10.1021/acs.est.2c08241")) estimated the human
toxicokinetic half-lives for a range of per- and poly-fluorinated alkyl 
substances (PFAS).</p>

data

High throughput toxicokinetics ("HTTK") is the
combination of 1) chemical-specific in vitro measurements or in
silico predictions and 2) generic mathematical models, to
predict absorption, distribution, metabolism, and excretion by the
body. HTTK methods have been described by Pearce et al. (2017)
(<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>).
Here we provide examples (vignettes) applying HTTK to solve various
problems in bioinformatics, toxicology, and exposure science.
In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>),
whenever a new HTTK model is developed, the code to generate the
figures evaluating that model is added as a new vignettte.

John Wambaugh

httkexamples

High-Throughput Toxicokinetics Examples

Robert Pearce

Caroline Ring

Greg Honda

Matt Linakis

Dustin Kapraun

Kimberly Truong

Meredith Scherer

Annabel Meade

Celia Schacht

Elaina Kenyon

wallis2023 function

Format

Wallis et al. 2023
Wallis et al. (2023) (tools:::Rd_expr_doi("10.1021/acs.est.2c08241")) estimated the human
toxicokinetic half-lives for a range of per- and poly-fluorinated alkyl 
substances (PFAS). — wallis2023

Wallis et al. 2023
Wallis et al. (2023) (tools:::Rd_expr_doi("10.1021/acs.est.2c08241")) estimated the human
toxicokinetic half-lives for a range of per- and poly-fluorinated alkyl 
substances (PFAS).

wallis2023: Wallis et al. 2023 Wallis et al. (2023) (tools:::Rd_expr_doi("10.1021/acs.est.2c08241")) estimated the human toxicokinetic half-lives for a range of per- and poly-fluorinated alkyl substances (PFAS).

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