immunogenetr (version 0.3.0)

HLA_mismatch_logical: HLA_mismatch_logical

Description

Determines if there are any mismatches between recipient and donor HLA alleles for the specified loci. Returns `TRUE` if mismatches are present, and `FALSE` otherwise.

Usage

HLA_mismatch_logical(GL_string_recip, GL_string_donor, loci, direction)

Value

A logical value (`TRUE` or `FALSE`): - `TRUE` if there are mismatches between recipient and donor HLA alleles. - `FALSE` if there are no mismatches.

Arguments

GL_string_recip

A GL strings representing the recipient's HLA genotypes.

GL_string_donor

A GL strings representing the donor's HLA genotypes.

loci

A character vector specifying the loci to be considered for mismatch calculation. HLA-DRB3/4/5 (and their serologic equivalents DR51/52/53) are considered once locus for this function, and should be called in this argument as "HLA-DRB3/4/5" or "HLA-DR51/52/53", respectively.

direction

A character string indicating the direction of mismatch. Options are "HvG" (host vs. graft), "GvH" (graft vs. host), "bidirectional" (if either "HvG" or "GvH" is TRUE), or "SOT" (host vs. graft, as is used for mismatching in solid organ transplantation).

Examples

file <- HLA_typing_1[, -1]
GL_string <- HLA_columns_to_GLstring(file, HLA_typing_columns = everything())

GL_string_recip <- GL_string[1]
GL_string_donor <- GL_string[2]

loci <- c("HLA-A", "HLA-DRB3/4/5", "HLA-DPB1")
mismatches <- HLA_mismatch_logical(GL_string_recip, GL_string_donor, loci, direction = "HvG")
print(mismatches)