crizer2024.clint: crizer2024vitro;textualinvitroTKdata Intrinsic Hepatic Clearance Level-2 Data Set

Description

Mass Spectrometry measurements of intrinsic hepatic clearance (Clint) for cryopreserved pooled human hepatocyte suspensions. Chemicals were per- and polyfluoroalkyl substance (PFAS) samples. The experiments were led by Dr. Crizer.

Usage

crizer2024.clint

Arguments

Format

A level-2 data.frame with 7,070 rows and 24 variables:

Lab.Sample.Name: Sample description used in the laboratory
Date: Date sample was acquired
Compound.Name: Compound name
DTXSID: DSSTox Substance Identifier (CompTox Chemicals Dashboard)
Lab.Compound.Name: Compound as described in the laboratory
Sample.Type: Type of Clint sample
Dilution.Factor: Number of times the sample was diluted
Calibration: Identifier for mass spectrometry calibration -- usually the date
ISTD.Name: Name of compound used as internal standard (ISTD)
ISTD.Conc: Concentration of ISTD (uM)
ISTD.Area: Peak area of internal standard (pixels)
Hep.Density: The density (units of millions of hepatocytes per mL) hepatocytes in the in vitro incubation
Std.Conc: Concentration of analytic standard (for calibration curve) (uM)
Clint.Assay.Conc: Intended initial concentration of chemical (uM)
Time: Time when sample was measured (h)
Area: Peak area of analyte (target compound)
Analysis.Method: General description of chemical analysis method
Analysis.Instrument: Instrument(s) used for chemical analysis)
Analysis.Parameters: Parameters for identifying analyte peak (for example, retention time)
Note: Any laboratory notes about sample
Level0.File: Name of data file from laboratory that was used to compile level-0 data.frame
Level0.Sheet: Name of "sheet" (for Excel workbooks) from which the laboratory data were read
Response: Response factor (calculated from analyte and ISTD peaks)
Verified: If "Y", then sample is included in the analysis. (Any other value causes the data to be ignored.)

References

crizer2024vitroinvitroTKdata