crizer2024.clint.L3

Crizer2024.clint.L3

Frequentist estimates of intrinsic hepatic clearance (Clint) for
cryopreserved pooled human hepatocyte suspensions. Chemicals were per- and
polyfluoroalkyl substance (PFAS) samples. The experiments were
led by Dr. Crizer.

datasets

A collection of datasets containing a variety of in vitro toxicokinetic
measurements including -- but not limited to -- chemical fraction unbound
in the presence of plasma (f_up), intrinsic hepatic clearance (Clint,
uL/min/million hepatocytes), and membrane permeability for
oral absorption (Caco2). The datasets provided by the package were
processed and analyzed with the companion 'invitroTKstats' package.

Caroline Ring

invitroTKdata

In Vitro Toxicokinetic Data Processed with the 'invitroTKstats'
Pipeline

Sarah E. Davidson-Fritz

John Wambaugh

Lindsay Knupp

Barbara A. Wetmore

Anna Kreutz

Marci Smeltz

David Crizer

U.S. Federal Government 

crizer2024.clint.L3 function

A level-3 data.frame with 60 rows and 13 variables:<dl>
<dt><code>Compound.Name</code></dt>
<dd>Compound name</dd><dt><code>DTXSID</code></dt>
<dd>DSSTox Substance Identifier (CompTox Chemicals Dashboard)</dd><dt><code>Lab.Compound.Name</code></dt>
<dd>Compound as described in the laboratory</dd><dt><code>Calibration</code></dt>
<dd>Identifier for mass spectrometry calibration -- usually the date</dd><dt><code>Clint</code></dt>
<dd>Frequentist point estimate for intrinsic hepatic clearance (Clint)</dd><dt><code>Clint.pValue</code></dt>
<dd>p-value of the estimated <code>Clint</code> value</dd><dt><code>Fit</code></dt>
<dd>Test nominal concentrations in the linear regression fit</dd><dt><code>AIC</code></dt>
<dd>Akaike Information Criterion (AIC) for the linear regression fit</dd><dt><code>AIC.Null</code></dt>
<dd>Akaike Information Criterion of the exponential decay assuming a constant rate of decay</dd><dt><code>Clint.1</code></dt>
<dd>Intrinsic hepatic clearance at 1 uM (frequentist point estimate)</dd><dt><code>Clint.10</code></dt>
<dd>Intrinsic hepatic clearance at 10 uM (frequentist point estimate)</dd><dt><code>AIC.Sat</code></dt>
<dd>Akaike Information Criterion of the exponential decay with a saturation probability</dd><dt><code>Sat.pValue</code></dt>
<dd>p-value of exponential decay with a saturation probability</dd>
</dl>

Format

crizer2024vitro;textualinvitroTKdata Intrinsic Hepatic Clearance Level-3 Data Set — crizer2024.clint.L3

A level-3 data.frame with 60 rows and 13 variables:<dl>
<dt><code>Compound.Name</code></dt>
<dd>Compound name</dd>

<dt><code>DTXSID</code></dt>
<dd>DSSTox Substance Identifier (CompTox Chemicals Dashboard)</dd>

<dt><code>Lab.Compound.Name</code></dt>
<dd>Compound as described in the laboratory</dd>

<dt><code>Calibration</code></dt>
<dd>Identifier for mass spectrometry calibration -- usually the date</dd>

<dt><code>Clint</code></dt>
<dd>Frequentist point estimate for intrinsic hepatic clearance (Clint)</dd>

<dt><code>Clint.pValue</code></dt>
<dd>p-value of the estimated <code>Clint</code> value</dd>

<dt><code>Fit</code></dt>
<dd>Test nominal concentrations in the linear regression fit</dd>

<dt><code>AIC</code></dt>
<dd>Akaike Information Criterion (AIC) for the linear regression fit</dd>

<dt><code>AIC.Null</code></dt>
<dd>Akaike Information Criterion of the exponential decay assuming a constant rate of decay</dd>

<dt><code>Clint.1</code></dt>
<dd>Intrinsic hepatic clearance at 1 uM (frequentist point estimate)</dd>

<dt><code>Clint.10</code></dt>
<dd>Intrinsic hepatic clearance at 10 uM (frequentist point estimate)</dd>

<dt><code>AIC.Sat</code></dt>
<dd>Akaike Information Criterion of the exponential decay with a saturation probability</dd>

<dt><code>Sat.pValue</code></dt>
<dd>p-value of exponential decay with a saturation probability</dd>


</dl>

crizer2024vitro;textualinvitroTKdata Intrinsic Hepatic Clearance Level-3 Data Set

crizer2024.clint.L3: crizer2024vitro;textualinvitroTKdata Intrinsic Hepatic Clearance Level-3 Data Set

Description

Usage

Arguments

Format

References